ABSTRACT
PURPOSE: To study the expression of HER2, p53 and Ki67 proteins in cystoplasties. METHODS: Sixty rats were distributed randomly into three groups of 20 animals. Bladder augmentation was held to increase with ileum (Group I), colon (Group II) and stomach (Group III). Tissue samples of neobladder was collected from each rat to its own control. The animals were sacrificed after 12 weeks. The neobladder was withdrawn for immunohistochemitry analysis of p53, HER2 and Ki67 expression. Wilcoxon and Mann-Whitney tests were used for statistical study. RESULTS: There were no significant changes in the expression of p53 and HER2 proteins. It was observed significant increase (p<0.0001) in Ki67 expression in all groups, when compared with their respective controls. When the study groups were compared with each other, there was increase of cell proliferation in the largest gastrocystoplasties in respect of ileocystoplasties (p=0.004) and colocystoplasties (p=0.003). CONCLUSION: We observed significant increase of cell proliferation characterized by Ki67 protein in the digestive tract of the ileocystoplasties, the colocystoplasties and the gastrocystoplasties and this increase was significantly greater in gastrocystoplasties.
Subject(s)
Animals , Colon/metabolism , Ileum/metabolism , /metabolism , Lower Gastrointestinal Tract/surgery , /metabolism , Stomach/metabolism , /metabolism , Urinary Bladder/surgery , Colon/transplantation , Immunohistochemistry , Ileum/transplantation , Lower Gastrointestinal Tract/metabolism , Rats, Wistar , Statistics, Nonparametric , Stomach/transplantation , Urinary Bladder/metabolismABSTRACT
Os cistos hepáticos ciliados são estruturas originadas do desenvolvimento embrionário anormal. Eles são raros e benignos, mas que necessitam de tratamento quando sintomáticos ou ao sofrerem malignização. Descrevemos um caso de uma paciente de 32 anos diagnosticada e tratada por videolaparoscopia após apresentar dor abdominal em epigástrio e hipocôndrio direito, náusea e disfagia.
Ciliated hepatic foregut cysts are structures from abnormal embryonic development. They are rare and benign, but need treatment when symptoms or undergo malignant transformation. We described a case report of a 32-years woman diagnosed and surgically treated after abdominal pain in the epigastrium and right hypochondrium, nausea and dysphagia.